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KMID : 0385620210250020022
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Korean Journal of Psychopathology
2021 Volume.25 No. 2 p.22 ~ p.29
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Volumetric Characteristics of Amygdala Nuclei in the Group of Geriatric Subclinical Depression
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Kwon Young-June
Lee Jeong-Whan
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Abstract
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Objectives : The purpose of this study was to identify the volumetric alterations of the amygdala and their association with geriatric subclinical depression.
Method : Eighteen and 19 subjects aged 65 and above were recruited for the subclinical depression and the control group, respectively. Subclinical depression was defined by a cut-off value of 8 points on the Short Geriatric Depression Scale and no diagnosis of clinical psychiatric disorders. Participants of both groups must have normal cognitive functions assessed using Mini-Mental Status Examination. T1-weighted magnetic resonance images were acquired using 3T magnetic resonance imaging scanner. Volumes of bilateral amygdala and their nuclei, and lateralization indexes were determined using FreeSurfer(version 7.1.1). Statistical methods of Mann-Whitney U test, and Analysis of Covariance were used.
Results : Volumes of the left and right amygdala were smaller in the geriatric subclinical depression group compared to the control group(p≤0.048). There were significant volume reductions in left lateral nucleus, left anterior amygdaloid area, right lateral nucleus, right basal nucleus, right accessory basal nucleus, right anterior amygdaloid area, right cortical nucleus and right paralaminar nucleus(p≤0.034).
Conclusion : Various regions of amygdala nuclei which are known to be associated with emotional processing were smaller in size in the group of geriatric subclinical depression. Further studies are warranted to identify the neurophysiological factors that provoke the amygdala volume reduction in geriatric subclinical depression.
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KEYWORD
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Geriatric subclinical depression, Amygdala, Lateralization
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